Human Adenylate Cyclase 6 (ADCY6) CLIA Kit
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Description
Human Adenylate Cyclase 6 (ADCY6) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | CLIA Kits |
| Immunogen Target | Adenylate Cyclase 6 (ADCY6) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.128 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | AC6,LCCS8,Adenylate cyclase type 6 |
| Background | CLIA Kits ADCY6 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ADCY6 is a transmembrane enzyme expressed abundantly in the cardiovascular system and kidneys. It is essential for cAMP production in response to G-protein-coupled receptor activation and is regulated by mechanical stimuli and forskolin. ADCY6 plays a key role in cardiac contraction, vascular smooth muscle relaxation, and renal water regulation. Disruption of ADCY6 function has been associated with cardiovascular diseases, including hypertension and heart failure, due to impaired cAMP-mediated signaling pathways in cardiac tissues.
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Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors(PubMed:17916776, PubMed:17110384). Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells(PubMed:17916776). Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion(By similarity). Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function(By similarity). Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol(PubMed:17916776). Contributes to bone cell responses to mechanical stimuli(By similarity).
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Human Adenylate Cyclase 6 (ADCY6) Protein
Recombinant Adenylate Cyclase 6 (ADCY6) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
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