Human Adenylate Cyclase 2, Brain (ADCY2) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein ADCY2
proveedor
Abbexareference
abx065152Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Adenylate Cyclase 2, Brain (ADCY2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ADCY2 is a transmembrane enzyme expressed widely in the central nervous system and cardiac tissues. It is activated by Gαs proteins and regulated by forskolin and calcium signaling. ADCY2 plays a central role in converting ATP to cAMP, which mediates various cellular responses, including neurotransmission, hormone signaling, and metabolism. It is particularly important in modulating synaptic communication and neuronal excitability. Mutations or alterations in ADCY2 expression have been associated with mood disorders, including schizophrenia and bipolar disorder, highlighting its significance in brain function.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Adenylate Cyclase 2, Brain (ADCY2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 29.6 kDa Observed MW (SDS-PAGE): 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala294-Thr525 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ADCY2
dry ice
No
availability
Shipped within 5-7 working days.
alias
AC2,HBAC2,ATP pyrophosphate-lyase 2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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