Adenylate Cyclase 2, Brain (ADCY2) Antibody
357.5€ (100 µg)
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name
Adenylate Cyclase 2, Brain (ADCY2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx038430
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the ADCY2 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Adenylate Cyclase 2, Brain (ADCY2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_020546 |
| Alias | AC2,HBAC2,ATP pyrophosphate-lyase 2 |
| Background | Antibody anti-ADCY2 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
ADCY2 is a transmembrane enzyme expressed widely in the central nervous system and cardiac tissues. It is activated by Gαs proteins and regulated by forskolin and calcium signaling. ADCY2 plays a central role in converting ATP to cAMP, which mediates various cellular responses, including neurotransmission, hormone signaling, and metabolism. It is particularly important in modulating synaptic communication and neuronal excitability. Mutations or alterations in ADCY2 expression have been associated with mood disorders, including schizophrenia and bipolar disorder, highlighting its significance in brain function.
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This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca (2+) /calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
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