Human Acyl-Coenzyme A Thioesterase 8 (ACOT8) Protein
234€ (5 µg)
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Name
Human Acyl-Coenzyme A Thioesterase 8 (ACOT8) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073398
Tested Applications
SDS-PAGE
Description
Acyl-CoA Thioesterase 8 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Acyl-CoProtein A Thioesterase 8 (ACOT8) |
| Host | E. coli |
| Assay Type | Activity: Not tested |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14734 |
| Alias | hTE,NAP1,PTE1,PTE2,PTE-1,PTE-2,HNAACTE,hACTE-III |
| Background | Protein ACOT8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACOT8 is a ubiquitously expressed peroxisomal enzyme that hydrolyzes a wide range of acyl-CoA substrates, from short- to long-chain fatty acids, contributing to diverse metabolic processes. It plays a vital role in peroxisomal β-oxidation, bile acid synthesis, and the detoxification of reactive lipid intermediates. ACOT8 is particularly active in tissues such as the liver, kidney, and adrenal glands, where it regulates lipid and energy metabolism under conditions of metabolic stress or dietary changes. It also modulates the availability of CoA, ensuring the proper functioning of CoA-dependent enzymes within peroxisomes. Dysregulation of ACOT8 activity has been implicated in metabolic syndromes, including obesity and non-alcoholic fatty liver disease, where altered lipid metabolism affects systemic energy balance. Its broad substrate specificity and enzymatic versatility make ACOT8 a critical player in maintaining peroxisomal and cellular metabolic homeostasis.
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