Acyl-Coenzyme A Thioesterase 8 (ACOT8) Antibody
52€ (10 µg)
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Name
Acyl-Coenzyme A Thioesterase 8 (ACOT8) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx014151
Tested Applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against ACOT8 protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acyl-Coenzyme A Thioesterase 8 (ACOT8) Immunogen: The antiserum was produced against synthesized peptide derived from internal of human ACOT8. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/40000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14734 |
| Alias | hTE,NAP1,PTE1,PTE2,PTE-1,PTE-2,HNAACTE,hACTE-III |
| Background | Antibody anti-ACOT8 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACOT8 is a ubiquitously expressed peroxisomal enzyme that hydrolyzes a wide range of acyl-CoA substrates, from short- to long-chain fatty acids, contributing to diverse metabolic processes. It plays a vital role in peroxisomal β-oxidation, bile acid synthesis, and the detoxification of reactive lipid intermediates. ACOT8 is particularly active in tissues such as the liver, kidney, and adrenal glands, where it regulates lipid and energy metabolism under conditions of metabolic stress or dietary changes. It also modulates the availability of CoA, ensuring the proper functioning of CoA-dependent enzymes within peroxisomes. Dysregulation of ACOT8 activity has been implicated in metabolic syndromes, including obesity and non-alcoholic fatty liver disease, where altered lipid metabolism affects systemic energy balance. Its broad substrate specificity and enzymatic versatility make ACOT8 a critical player in maintaining peroxisomal and cellular metabolic homeostasis.
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