Human Activin Receptor Type-1B (ACVR1B) Protein

Este producto es parte de ACVR - Activin A Receptor Type
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546€ (100 µg)

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935106861
info@markelab.com
name
Human Activin Receptor Type-1B (ACVR1B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx620418
tested applications
ELISA, WB, SDS-PAGE

Description

Human Activin Receptor Type-1B (ACVR1B) Protein is a recombinant Human protein produced in a Mammalian cell expression system.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Activin Receptor Type-1B (ACVR1B)
Host
Mammalian cells
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 14.55 kDa
Sequence Fragment: Met1-Glu126
Tag: C-terminal His tag
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
100 µg
Size 2
1 mg
Form
Lyophilized Reconstitute in sterile water to produce a stock solution.
Tested Applications
ELISA, WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Availability
Shipped within 5-12 working days.
Storage
Store at 2-8 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C for long-term storage. Avoid repeated freeze-thaw cycles.
Dry Ice
No
UniProt ID
P36896
Alias
ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)
Background
Protein ACVR1B
Note
This product is for research use only. This product is shipped with ice packs.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

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Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2(ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors(ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.

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