Name: Activin A Receptor Type 1B (ACVR1B) Antibody
Brand: Abbexa
SKU: abx004175
Price: 175 EUR
Availability: OnlineOnly

Descripción

ACVR1B Antibody is a Rabbit Polyclonal antibody against ACVR1B. This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

Background

ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.

Características del producto

clonality

Polyclonal

reactivity

Human, Mouse

immunogen target

Activin A Receptor Type 1B (ACVR1B)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

purification

Purified by affinity chromatography.

buffer

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

size 1

20 µl

size 2

50 µl

size 3

100 µl

size 4

200 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ACVR1B

dry ice

availability

Shipped within 5-10 working days.

alias

ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)

uniprot id

https://www.uniprot.org/uniprotkb/P36896

gene id

https://www.ncbi.nlm.nih.gov/gene/91

NCBI accession

NP_004293.1

note

This product is for research use only.

Quizá le pueda interesar

anti- ACVR1B antibody

proveedor

FineTest

reference

FNab00129

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor ...

Precio a consultar

Recombinant Human ACVR1B