Name: Activin A Receptor Type 1B (ACVR1B) Antibody
Brand: Abbexa
SKU: abx025223
Price: 281.25 EUR
Availability: OnlineOnly

Descripción

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.

Background

ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.

Características del producto

clonality

Monoclonal

reactivity

Mouse

immunogen target

Activin A Receptor Type 1B (ACVR1B)

host

Mouse

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, WB

purification

Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

buffer

PBS containing 0.09% sodium azide.

size 1

80 µl

size 2

400 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

ACVR1B

dry ice

availability

Shipped within 5-10 working days.

alias

ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)

uniprot id

https://www.uniprot.org/uniprotkb/P36896

note

This product is for research use only.

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anti- ACVR1B antibody

proveedor

FineTest

reference

FNab00129

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor ...

Precio a consultar

Recombinant Human ACVR1B