Activin A Receptor Type 1B (ACVR1B) Antibody
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935106861
info@markelab.com
Precio
281.25€ (80 µl)
Antibody anti-ACVR1B
proveedor
Abbexareference
abx025223Tested Applications
ELISA, WBreactivity
Mousestatus
RUOclonality
MonoclonalDescripción
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.
Background
ACVR1B, also known as ALK4, is a type I receptor primarily activated by activins, inhibins, and Nodal ligands. This receptor phosphorylates SMAD2/3 to propagate downstream signaling, which regulates cellular processes such as differentiation, proliferation, and embryonic patterning. ACVR1B is expressed in many tissues, particularly during early development. Mutations in ACVR1B have been associated with tumorigenesis and reproductive disorders due to its role in cell cycle regulation and tissue homeostasis.
Características del producto
category
Primary Antibodies
clonality
Monoclonal
reactivity
Mouse
immunogen target
Activin A Receptor Type 1B (ACVR1B)
host
Mouse
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ACVR1B
dry ice
No
availability
Shipped within 5-10 working days.
alias
ACTR-IB,ALK-4,Serine/threonine-protein kinase receptor R2 (SKR2)
uniprot id
note
This product is for research use only.
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