Human Actinin Alpha 4 (ACTN4) CLIA Kit

Este producto es parte de ACTN - Actinin Alpha
Human Actinin Alpha 4 (ACTN4) CLIA Kit
845€ (96 tests)

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Name
Human Actinin Alpha 4 (ACTN4) CLIA Kit
Category
CLIA Kits
Provider
Abbexa
Reference
abx493552
Tested Applications
CLIA

Description

Human Actinin alpha 4 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
CLIA Kits
Immunogen Target
Actinin Alpha 4 (ACTN4)
Reactivity
Human
Detection Method
Chemiluminescent
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.14 ng/ml - 100 ng/ml
Sensitivity
< 0.07 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Standard: Lyophilized
Tested Applications
CLIA
Sample Type
Tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.
Availability
Shipped within 5-20 working days.
Storage
Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
Alias
ACTN4,ACTININ-4,FSGS,FSGS1
Background
CLIA Kits ACTN4
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES.  The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.  Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.

Background

ACTN4 encodes alpha-actinin-4, a non-muscle isoform of the actinin family that plays a critical role in cellular motility, adhesion, and signal transduction. It is widely expressed in various tissues, where it crosslinks actin filaments and interacts with focal adhesion proteins to regulate cytoskeletal organization and mechanotransduction. ACTN4 is particularly important in podocytes of the kidney, where it contributes to the maintenance of glomerular filtration barrier integrity. Mutations in ACTN4 are associated with focal segmental glomerulosclerosis (FSGS), a kidney disease characterized by proteinuria and progressive renal failure. In addition to its structural role, ACTN4 is implicated in cancer metastasis and cell invasion, reflecting its involvement in dynamic cellular processes. Its diverse functions in cytoskeletal dynamics and signal regulation highlight its importance in cellular stability and adaptability.

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