Human A-Kinase Anchor Protein 4 (AKAP4) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for AKAP4
proveedor
Abbexareference
abx385685Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human A-Kinase Anchor Protein 4 (AKAP4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human A Kinase Anchor Protein 4 (AKAP4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
AKAP4 is a key sperm-specific scaffold protein located in the fibrous sheath of the sperm tail, where it plays a vital role in flagellar structure, motility, and energy metabolism. It anchors PKA and other enzymes, organizing cAMP-dependent signaling pathways that regulate phosphorylation events necessary for sperm motility and capacitation. AKAP4 interacts with structural proteins to maintain the stability and flexibility of the sperm tail, ensuring proper flagellar beating. Loss or dysfunction of AKAP4 results in reduced sperm motility, structural defects in the sperm flagellum, and male infertility. AKAP4 is essential for mitochondrial energy generation by organizing signaling complexes that regulate ATP production in the midpiece of sperm cells. Recent studies suggest AKAP4 as a diagnostic marker for sperm quality, as its expression correlates with sperm motility and fertility outcomes in males.
Características del producto
category
ELISA Kits
immunogen target
A-Kinase Anchor Protein 4 (AKAP4)
reactivity
Human
test range
0.313 ng/ml - 20 ng/ml
sensitivity
< 0.19 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
PRKA4,AKAP-4
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
AKAP4
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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proveedor
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FNab00256Tested Applications
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polyclonalMajor structural component of sperm fibrous sheath. Plays a role in sperm motility.
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