A-Kinase Anchor Protein 4 (AKAP4) Antibody
364€ (100 µg)
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935106861
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name
A-Kinase Anchor Protein 4 (AKAP4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230256
tested applications
ELISA, WB, IHC
Description
AKAP4 Antibody is a Rabbit Polyclonal against AKAP4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | A-Kinase Anchor Protein 4 (AKAP4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/5000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q5JQC9 |
| Gene ID | 8852 |
| OMIM | 300185 |
| Alias | PRKA4,AKAP-4 |
| Background | Antibody anti-AKAP4 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
AKAP4 is a key sperm-specific scaffold protein located in the fibrous sheath of the sperm tail, where it plays a vital role in flagellar structure, motility, and energy metabolism. It anchors PKA and other enzymes, organizing cAMP-dependent signaling pathways that regulate phosphorylation events necessary for sperm motility and capacitation. AKAP4 interacts with structural proteins to maintain the stability and flexibility of the sperm tail, ensuring proper flagellar beating. Loss or dysfunction of AKAP4 results in reduced sperm motility, structural defects in the sperm flagellum, and male infertility. AKAP4 is essential for mitochondrial energy generation by organizing signaling complexes that regulate ATP production in the midpiece of sperm cells. Recent studies suggest AKAP4 as a diagnostic marker for sperm quality, as its expression correlates with sperm motility and fertility outcomes in males.
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