Human A-Kinase Anchor Protein 12 (AKAP12) ELISA Kit
585€ (96 tests)
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name
Human A-Kinase Anchor Protein 12 (AKAP12) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx251991
tested applications
ELISA
Description
Human A-Kinase Anchor Protein 12 (AKAP12) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human A-Kinase Anchor Protein 12 (AKAP12) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | A-Kinase Anchor Protein 12 (AKAP12) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 15.63 pg/ml - 1000 pg/ml |
| Sensitivity | 9.38 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q02952 |
| Gene ID | 9590 |
| OMIM | 604698 |
| Alias | AKAP250,SSeCKS |
| Background | Elisa kits for AKAP12 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
AKAP12, also known as gravin, is a multifunctional scaffold protein that binds PKA, PKC, and other kinases, organizing signaling pathways at the plasma membrane and cytoskeleton. AKAP12 plays a critical role in cell adhesion, migration, and proliferation by coordinating cAMP and PKC signaling in focal adhesions. It regulates cytoskeletal remodeling and cell polarity by interacting with actin-binding proteins, influencing processes like wound healing and cancer metastasis. AKAP12 acts as a tumor suppressor in various cancers, where its loss leads to dysregulated signaling pathways, including ERK/MAPK and cell cycle progression. AKAP12 is also involved in vascular homeostasis, where it regulates endothelial barrier function and angiogenesis. Studies highlight AKAP12’s role in stress responses, particularly in regulating PKA signaling during inflammation and oxidative stress. Additionally, AKAP12 expression is regulated by epigenetic mechanisms, such as promoter methylation, which contributes to its silencing in cancer cells.
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