Human A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) Protein
221€ (10 µg)
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935106861
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name
Human A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx065082
tested applications
WB, SDS-PAGE
Description
Human A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 7.6 kDa Observed MW (SDS-PAGE): 13 kDa Possible reasons why the actual band size differs from the predicted band size: 1. Splice variants. Alternative splicing may create different sized proteins from the same gene. 2. Relative charge. The composition of amino acids may affect the charge of the protein. 3. Post-translational modification. Phosphorylation, glycoslyation, methylation etc. may affect the band size. 4. Post-translational cleavage. Many proteins are synthesised as pro-proteins, and then cleaved to give the active form. 5. Polymerisation of the target protein. Dimerisation, multimerisation etc. will increase the band size observed. Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu832-Leu889 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UP79 |
| Alias | METH2,Type 1 Motif 8,A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8,ADAM-TS 8,ADAM-TS8 |
| Background | Protein ADAMTS8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ADAMTS8 (A Disintegrin And Metalloproteinase with Thrombospondin Motifs 8) is another member of the ADAMTS family of proteases. Similar to other members of the ADAMTS family, ADAMTS8 contains several characteristic domains, including a metalloproteinase domain, a disintegrin-like domain, and thrombospondin type-1 (TSP-1) motifs. These domains play essential roles in substrate recognition, protein-protein interactions, and enzymatic activity. ADAMTS8 is expressed in various tissues, including the brain, heart, cartilage, and skeletal muscle. Its expression pattern suggests potential roles in tissue development, maintenance, and remodeling. ADAMTS8 is involved in various physiological processes, particularly in extracellular matrix (ECM) remodeling. It plays a role in the turnover and organization of ECM components, including proteoglycans and collagens. Additionally, ADAMTS8 has been implicated in angiogenesis, wound healing, and inflammation. Dysregulation of ADAMTS8 has been associated with several diseases and conditions. For example, ADAMTS8 has been implicated in cancer progression, where it may influence tumor growth, invasion, and metastasis through its effects on the ECM and angiogenesis. Additionally, mutations in the ADAMTS8 gene have been linked to certain developmental disorders and connective tissue diseases.
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