Human 5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A) CLIA Kit

Product specifications

CLIA Kits

5-Hydroxytryptamine Receptor 1A / 5-HT1A (HTR1A)

Human

Chemiluminescent

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.059 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

CLIA

Tissue homogenates, cell lysates and other biological fluids.

Shipped within 5-20 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

HTR1A,G-21,5HT1a,PFMCD,5-HT1A,5-HT-1A,ADRBRL1,ADRB2RL1,5-HT1A receptor

CLIA Kits HTR1A

RUO

The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

HTR1A, a subtype of the serotonin receptor family, is a G protein-coupled receptor (GPCR) responsible for mediating the effects of serotonin (5-HT), a neurotransmitter essential for regulating mood, anxiety, and behavior. Predominantly expressed in the central nervous system, particularly in regions such as the hippocampus, cerebral cortex, and raphe nuclei, HTR1A plays a key role in modulating neuronal excitability and synaptic transmission. Activation of HTR1A leads to the inhibition of adenylyl cyclase, reducing cyclic AMP (cAMP) levels and promoting cellular hyperpolarization, which reduces neuronal firing. Dysregulation of HTR1A has been associated with mood disorders such as depression, anxiety, and schizophrenia, making it a key target for anxiolytic and antidepressant drugs such as SSRIs (selective serotonin reuptake inhibitors) and buspirone. Additionally, HTR1A is involved in neurogenesis, stress response regulation, and cognitive function. Emerging evidence suggests that HTR1A also has neuroprotective properties by reducing oxidative stress, modulating mitochondrial function, and preventing apoptosis in neurons. HTR1A's diverse roles in mood regulation, stress resilience, and cognitive function make it a significant therapeutic target for treating mood disorders, neurodegenerative diseases, and cognitive dysfunction. Ongoing research is investigating its potential for enhancing neuroplasticity and stress resilience in mental health disorders.

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This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers.

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