Human 14-3-3 Protein Beta/Alpha (YWHAB) ELISA Kit
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Pida mas información
935106861
info@markelab.com
Precio
578.5€ (96 tests)
Elisa kits for YWHAB
proveedor
Abbexareference
abx257488Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human 14-3-3 protein Beta/Alpha (YWHAB) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human YWHAB (14-3-3 protein Beta/Alpha) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
YWHAB, part of the 14-3-3 protein family, functions as a scaffold protein that binds to phosphorylated serine/threonine-containing motifs, regulating protein localization, stability, and signaling pathways. It is involved in processes such as cell cycle control, DNA damage response, apoptosis, and stress adaptation by interacting with key signaling proteins, including Raf kinases, BAD, and CDC25. YWHAB regulates pathways like MAPK and PI3K/Akt, influencing cellular growth, survival, and metabolism. It is ubiquitously expressed, with high levels in the brain, where it contributes to synaptic plasticity, neuroprotection, and neuronal development. Dysregulation of YWHAB has been associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, as well as cancer, where altered protein interactions promote tumor survival and metastasis. Knockout studies show defects in cellular proliferation, increased apoptosis, and impaired stress responses, highlighting its role in maintaining cellular stability and signaling balance.
Características del producto
category
ELISA Kits
immunogen target
14-3-3 Protein Beta/Alpha (YWHAB)
reactivity
Human
test range
1.56 ng/ml - 100 ng/ml
sensitivity
< 0.63 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta,14-3-3 alpha,14-3-3 beta
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
YWHAB
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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