935106861
info@markelab.com
Precio
300€ (100 µg)
14-3-3 beta/alpha Antibody is a Mouse Monoclonal antibody against Human, Mouse and Rat.
YWHAB, part of the 14-3-3 protein family, functions as a scaffold protein that binds to phosphorylated serine/threonine-containing motifs, regulating protein localization, stability, and signaling pathways. It is involved in processes such as cell cycle control, DNA damage response, apoptosis, and stress adaptation by interacting with key signaling proteins, including Raf kinases, BAD, and CDC25. YWHAB regulates pathways like MAPK and PI3K/Akt, influencing cellular growth, survival, and metabolism. It is ubiquitously expressed, with high levels in the brain, where it contributes to synaptic plasticity, neuroprotection, and neuronal development. Dysregulation of YWHAB has been associated with neurodegenerative diseases, including Alzheimer’s and Parkinson’s, as well as cancer, where altered protein interactions promote tumor survival and metastasis. Knockout studies show defects in cellular proliferation, increased apoptosis, and impaired stress responses, highlighting its role in maintaining cellular stability and signaling balance.
Primary Antibodies
Monoclonal
Human, Mouse, Rat
14-3-3 Beta/alpha (YWHAB)
Mouse
Unconjugated
Liquid
WB, IHC-P, IF/ICC
Purified by Protein A or Protein G.
TBS, pH 7.4, 0.5% BSA, 25% glycerol and 0.05% sodium azide.
100 µg
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
YWHAB
No
Shipped within 5-10 working days.
YWHAB, GW128, HEL-S-1, HS1, KCIP-1, YWHAA, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta,14-3-3 alpha,14-3-3 beta
This product is for research use only.
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