HRH1 (pS398) Antibody
429€ (100 µl)
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Name
HRH1 (pS398) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx332952
Tested Applications
ELISA, IF/ICC
Description
HRH1 (pS398) Antibody is a Rabbit Polyclonal against HRH1 (pS398).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: HRH1 (pS398) Immunogen: Peptide sequence around phosphorylation site of Serine 398 (S-H-S (p)-R-Q) derived from Human Histamine H1 Receptor. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35367 |
| Alias | HRH1,H1R,HH1R,Hisr,H1-R,hisH1 |
| Background | Antibody anti-HRH1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
HRH1 is a G protein-coupled receptor activated by histamine, a biogenic amine involved in allergic responses, inflammation, and neurotransmission. HRH1 is widely expressed in smooth muscle cells, endothelial cells, and the central nervous system. Upon activation, HRH1 couples to Gq/11 proteins, leading to activation of phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC) signaling. In peripheral tissues, HRH1 mediates allergic and inflammatory responses by inducing vasodilation, increased vascular permeability, and smooth muscle contraction, contributing to symptoms like itching, bronchoconstriction, and edema. In the central nervous system, HRH1 modulates wakefulness, appetite regulation, and cognition. Dysregulation of HRH1 is associated with allergic conditions, including rhinitis, urticaria, and asthma. HRH1 antagonists, such as antihistamines, are widely used to treat allergic reactions and inflammatory conditions. HRH1 also plays roles in neuroinflammation and psychiatric disorders like anxiety and schizophrenia, where altered histamine signaling disrupts neurological balance.
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