Histamine Receptor H1 (HRH1) Antibody
292.5€ (80 µl)
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935106861
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name
Histamine Receptor H1 (HRH1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028046
tested applications
ELISA, WB, IHC
Description
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Histamine Receptor H1 (HRH1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P35367 |
| Alias | HRH1,H1R,HH1R,Hisr,H1-R,hisH1 |
| Background | Antibody anti-HRH1 |
| Status | RUO |
Descripción
HRH1 is a G protein-coupled receptor activated by histamine, a biogenic amine involved in allergic responses, inflammation, and neurotransmission. HRH1 is widely expressed in smooth muscle cells, endothelial cells, and the central nervous system. Upon activation, HRH1 couples to Gq/11 proteins, leading to activation of phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC) signaling. In peripheral tissues, HRH1 mediates allergic and inflammatory responses by inducing vasodilation, increased vascular permeability, and smooth muscle contraction, contributing to symptoms like itching, bronchoconstriction, and edema. In the central nervous system, HRH1 modulates wakefulness, appetite regulation, and cognition. Dysregulation of HRH1 is associated with allergic conditions, including rhinitis, urticaria, and asthma. HRH1 antagonists, such as antihistamines, are widely used to treat allergic reactions and inflammatory conditions. HRH1 also plays roles in neuroinflammation and psychiatric disorders like anxiety and schizophrenia, where altered histamine signaling disrupts neurological balance.
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In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
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