Histamine Receptor H1 (HRH1) Antibody (FITC)

Este producto es parte de HRH - histamine receptor H
Histamine Receptor H1 (HRH1) Antibody (FITC)

Pida mas información

935106861

info@markelab.com

Precio

169€ (20 µg)

Antibody anti-HRH1

proveedor

Abbexa

reference

abx316948

Tested Applications

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

HRH1 Antibody (FITC) is a Rabbit Polyclonal against HRH1 conjugated to FITC.


Background

HRH1 is a G protein-coupled receptor activated by histamine, a biogenic amine involved in allergic responses, inflammation, and neurotransmission. HRH1 is widely expressed in smooth muscle cells, endothelial cells, and the central nervous system. Upon activation, HRH1 couples to Gq/11 proteins, leading to activation of phospholipase C (PLC), calcium mobilization, and protein kinase C (PKC) signaling. In peripheral tissues, HRH1 mediates allergic and inflammatory responses by inducing vasodilation, increased vascular permeability, and smooth muscle contraction, contributing to symptoms like itching, bronchoconstriction, and edema. In the central nervous system, HRH1 modulates wakefulness, appetite regulation, and cognition. Dysregulation of HRH1 is associated with allergic conditions, including rhinitis, urticaria, and asthma. HRH1 antagonists, such as antihistamines, are widely used to treat allergic reactions and inflammatory conditions. HRH1 also plays roles in neuroinflammation and psychiatric disorders like anxiety and schizophrenia, where altered histamine signaling disrupts neurological balance.

Características del producto

category

Primary Antibodies


clonality

Polyclonal


reactivity

Human


immunogen target

Histamine Receptor H1 (HRH1)


host

Rabbit


isotype

IgG


conjugation

FITC


form

Liquid


purity

> 95%


purification

Purified by Protein G.


recommended dilution

Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.


size 1

20 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

1 mg


storage

Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.


or code

HRH1


dry ice

No


availability

Shipped within 5-10 working days.


alias

HRH1,H1R,HH1R,Hisr,H1-R,hisH1


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