Growth Hormone Binding Protein (GHBP) ELISA

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510€ (96 det.)

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935106861
info@markelab.com
name
Growth Hormone Binding Protein (GHBP) ELISA
category
ELISA Kits
provider
Mediagnost
reference
E024
tested applications
Elisa

Description

Quantitative measurement of human Growth Hormone Binding Protein levels in serum or plasma, for research use.

Documents del producto

Instrucciones
Descargar
Data sheet

Product specifications

Category
ELISA Kits
Reactivity
Human
Assay Data
Reference Material: recombinant GHBP
Incubation Period: 3h
Calibrator: GHBP
Controls: 2 control sera, freeze-dried - RiliBäK conform
Assay Type
Sandwich
Test Range
0.009 - 84 ng/mL
Sensitivity
0.009 µg/L
Recommended Dilution
1:21
Origin
Antibody: Rabbit
Size 1
96 det.
Tested Applications
Elisa
Sample Type
Serum
EDTA / Heparin Plasma
Availability
3-5 days.
Storage
Shelf life: between 1 and 2 years
Store the kit at 2-8°C after receipt until its expiry date
Alias
growth hormone receptor
Background
Elisa Kits for: GHR
Status
RUO
Note
Intra/Interassay Variance [%]<10

Descripción

Kit para la medición cuantitativa de los niveles de human Growth Hormone Binding Protein en suero o plasma, para uso en investigación.

Growth Hormone Binding Protein (GHBP) consists of 238 amino acids and includes four sides for glycosylation and three disulphide bounds. In humans GHBP is formed by receptor shedding of the growth hormone receptor by a metalloprotease (ADAM17). In equilibrium about 50% of circulating growth hormone (GH) is bound to GHBP but only 2% of the circulating GHBP bound a GH molecule with a stoichiometry of 1:1. Only in case of supraphysiological GHBP levels a 2:1 ratio appears. The complex of GH and GHBP has an approximate molecular weight of 80 kDa (GHBP 60 kDa). In an animal model (guinea pig) the complex formation increases half-life from 11-20 minutes up to about 100 minutes and in general binding to GHBP inhibits GH cellular action.

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