Growth Differentiation Factor 15 (GDF15) Antibody

Este producto es parte de GDF15 - Growth Differentiation Factor 15
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195€ (20 µl)

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935106861
info@markelab.com
name
Growth Differentiation Factor 15 (GDF15) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx000584
tested applications
ELISA, WB, IHC, IF/ICC, IP

Description

GDF15 Antibody is a Rabbit Polyclonal antibody against GDF15. Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Growth Differentiation Factor 15 (GDF15)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
20 µl
Size 2
100 µl
Size 3
2 × 100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Buffer
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q99988
Gene ID
9518
NCBI Accession
NP_004855.2
Alias
HG,PDF,MIC1;,PLAB,MIC-1,NAG-1,PTGFB, GDF-15
Background
Antibody anti-GDF15
Status
RUO
Note
Concentration: > 0.2 mg/ml -

Descripción

GDF15, a stress-responsive cytokine, stands as a distinct member within the diverse TGF-β superfamily. Its expression is typically low in most tissues during normal physiological conditions. However, when cardiac myocytes face ischemia or heightened ventricular wall stress, GDF-15 expression intensifies significantly. This cytokine has emerged as a potent prognostic indicator in various diseases, including heart diseases and cancer. Interestingly, it appears to act protectively against cardiac injury, attributed to its antihypertrophic, antiapoptotic, and anti-inflammatory properties, although the specific receptor through which GDF-15 exerts its effects remains unidentified. Studies have revealed a positive correlation between elevated GDF-15 levels and factors such as LV mass, IL-6, and MMP-9 levels in patients with heart failure (HF)

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