Growth Differentiation Factor 15 (GDF15) Antibody
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935106861
info@markelab.com
Precio
195€ (20 µl)
Antibody anti-GDF15
proveedor
Abbexareference
abx000584Tested Applications
ELISA, WB, IHC, IF/ICC, IPreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
GDF15 Antibody is a Rabbit Polyclonal antibody against GDF15. Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
Background
GDF15, a stress-responsive cytokine, stands as a distinct member within the diverse TGF-β superfamily. Its expression is typically low in most tissues during normal physiological conditions. However, when cardiac myocytes face ischemia or heightened ventricular wall stress, GDF-15 expression intensifies significantly. This cytokine has emerged as a potent prognostic indicator in various diseases, including heart diseases and cancer. Interestingly, it appears to act protectively against cardiac injury, attributed to its antihypertrophic, antiapoptotic, and anti-inflammatory properties, although the specific receptor through which GDF-15 exerts its effects remains unidentified. Studies have revealed a positive correlation between elevated GDF-15 levels and factors such as LV mass, IL-6, and MMP-9 levels in patients with heart failure (HF)
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Growth Differentiation Factor 15 (GDF15)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IF/ICC, IP
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
size 1
20 µl
size 2
100 µl
size 3
2 × 100 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
GDF15
dry ice
No
availability
Shipped within 5-10 working days.
alias
HG,PDF,MIC1;,PLAB,MIC-1,NAG-1,PTGFB, GDF-15
uniprot id
NCBI accession
NP_004855.2
note
Concentration: > 0.2 mg/ml -
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