Growth Differentiation Factor 15 (GDF15) Antibody
195€ (20 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Growth Differentiation Factor 15 (GDF15) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx000584
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Description
GDF15 Antibody is a Rabbit Polyclonal antibody against GDF15. Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Growth Differentiation Factor 15 (GDF15) Immunogen: Recombinant protein corresponding to GDF15. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 0.5 µg - 4 µg antibody per 200 µg - 400 µg extracts of whole cells. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 34 kDa Observed MW: 35 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, IP |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99988 |
| Gene ID | 9518 |
| NCBI Accession | NP_004855.2 |
| Alias | HG,PDF,MIC1;,PLAB,MIC-1,NAG-1,PTGFB, GDF-15 |
| Background | Antibody anti-GDF15 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
GDF15, a stress-responsive cytokine, stands as a distinct member within the diverse TGF-β superfamily. Its expression is typically low in most tissues during normal physiological conditions. However, when cardiac myocytes face ischemia or heightened ventricular wall stress, GDF-15 expression intensifies significantly. This cytokine has emerged as a potent prognostic indicator in various diseases, including heart diseases and cancer. Interestingly, it appears to act protectively against cardiac injury, attributed to its antihypertrophic, antiapoptotic, and anti-inflammatory properties, although the specific receptor through which GDF-15 exerts its effects remains unidentified. Studies have revealed a positive correlation between elevated GDF-15 levels and factors such as LV mass, IL-6, and MMP-9 levels in patients with heart failure (HF)
Productos relacionados
Growth Differentiation Factor 15 (GDF15) Antibody
GDF15 Antibody is a Rabbit Polyclonal antibody against GDF15. Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are m…
Ver producto
Growth Differentiation Factor 15 (GDF15) Antibody
Rabbit polyclonal antibody against GDF15 protein. Immunogen region is Internal.…
Ver producto
Human Growth Differentiation Factor 15 (GDF15) Protein
Human Growth Differentiation Factor 15 (GDF15) is a recombinant Human protein expressed in E. coli.…
Ver producto