GP145-TrkC (TRKC) Antibody
Pida mas información
935106861
info@markelab.com
Precio
250€ (80 µl)
Antibody anti-NTRK3
proveedor
Abbexareference
abx033618Tested Applications
ELISA, WB, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
TRKC, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
Background
Neurotrophic receptor tyrosine kinase 3 (NTRK3), also known as TrkC, binds primarily with neurotrophin-3 (NT-3) and is integral to the proper development and function of both the central and peripheral nervous systems. This receptor promotes neuronal survival, axonal growth, and the guidance of neuronal connections during development. Dysfunctions in NTRK3 signaling pathways are linked to developmental disorders, including autism spectrum disorders and some cancers, such as medulloblastomas. Its role in neurodevelopment and oncology continues to be a focus of significant clinical research.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
GP145-TrkC (TRKC)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC
purification
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
NTRK3
dry ice
No
availability
Shipped within 5-10 working days.
alias
TRKC,GP145-TrkC,gp145(trkC),TrkC tyrosine kinase,Neurotrophic tyrosine kinase receptor type 3,NT-3 growth factor receptor
uniprot id
note
This product is for research use only.
Quizá le pueda interesar
Human NTRK3(Neurotrophic Tyrosine Kinase Receptor Type 3) ELISA Kit
proveedor
FineTestreference
EH3448reactivity
humanstatus
RUOPrecio a consultar
Ver másanti- TrkC antibody
proveedor
FineTestreference
FNab09003Tested Applications
ELISA, WBreactivity
humanstatus
RUOclonality
polyclonalPrecio a consultar
Ver másNeurotrophic Tyrosine Kinase Receptor Type 3 (NTRK3) Antibody
proveedor
Abbexareference
abx004480Tested Applications
WB, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalNTRK3 Antibody is a Rabbit Polyclonal antibody against NTRK3. This gene encodes a member of the neurotrophic tyrosine re...
175€ (20 µl)
Ver más