Goat Melatonin Receptor 1A (MTNR1A) Protein

Este producto es parte de MTNR - Melatonin Receptor
Goat Melatonin Receptor 1A (MTNR1A) Protein

Pida mas información

935106861

info@markelab.com

Precio

442€ (50 µg)

Protein MTNR1A

proveedor

Abbexa

reference

abx067985

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Melatonin Receptor 1A (MTNR1A) is a recombinant Goat protein produced in a Prokaryotic expression system (E. coli).


Background

MTNR1A, also known as MT1, is a G protein-coupled receptor for melatonin, a hormone secreted by the pineal gland that regulates circadian rhythms and sleep-wake cycles. MTNR1A is primarily expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, where it mediates melatonin’s effects on synchronizing circadian rhythms with environmental light-dark cycles. Activation of MTNR1A inhibits adenylate cyclase via Gi proteins, reducing cAMP levels and modulating downstream signaling pathways that regulate neuronal excitability and gene expression. MTNR1A is critical for sleep initiation, thermoregulation, and seasonal reproduction in some species. Dysregulation of MTNR1A has been associated with sleep disorders, circadian rhythm disturbances, and mood disorders such as depression. MTNR1A agonists like ramelteon are used clinically to treat insomnia and jet lag by promoting sleep onset. Its role in circadian and endocrine regulation highlights MTNR1A as a key target for managing sleep disorders, metabolic health, and mood-related conditions.

Características del producto

category

Proteins and Peptides


origin

Goat


host

E. coli


immunogen target

Melatonin Receptor 1A (MTNR1A)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

50 µg


size 2

100 µg


size 3

200 µg


size 4

500 µg


size 5

1 mg


observerd MW

Molecular Weight: Calculated MW: 12.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly312-Val366 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

MTNR1A


dry ice

No


availability

Shipped within 5-12 working days.


alias

MTNR1A,mel1a receptor,MelR,MEL-1A-R, MT1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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