Glycophorin-B (GYPB) Antibody

Este producto es parte de GYPB - glycophorin B
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Glycophorin-B (GYPB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx027545
tested applications
ELISA, WB, IHC

Description

This protein is a minor sialoglycoprotein in erythrocyte membranes.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Glycophorin-B (GYPB)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P06028
Alias
MNS blood group,SS,GPB,GYP,MNS,GYPA,PAS-3,CD235b,SS-active sialoglycoprotein,Sialoglycoprotein delta
Background
Antibody anti-GYPB
Status
RUO

Descripción

Glycophorin B (GYPB) is a glycoprotein found on the surface of human red blood cells (RBCs), encoded by the GYPB gene. GYPB, along with its closely related counterpart Glycophorin A (GYPA), is integral to the erythrocyte membrane's structure and function and contributes to the MNS blood group system, which is important in transfusion medicine. The MNS blood group antigens, primarily expressed on GYPA and GYPB, define variations in RBC surfaces and can provoke immune responses in transfusion and transplantation contexts. The Ss antigens, present specifically on GYPB, are responsible for variations in RBC surfaces and are known for their immunogenic properties. Besides its role in the blood group system, GYPB contributes to the physical properties of RBCs and plays a role in host-pathogen interactions. The gene encoding GYPB is highly homologous to GYPA, and these two genes likely originated through gene duplication and share considerable sequence identity. GYPB's specific structural characteristics and glycosylation pattern contribute to its interactions with pathogens, making it relevant in infectious disease dynamics, especially in malaria research, given that certain Plasmodium species use glycophorins to invade RBCs.

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