Glutathione Hydrolase 6 (GGT6) Antibody
292.5€ (80 µl)
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935106861
info@markelab.com
name
Glutathione Hydrolase 6 (GGT6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx029563
tested applications
ELISA, WB
Description
GGT6 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Glutathione Hydrolase 6 (GGT6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6P531 |
| Alias | Gamma-glutamyltranspeptidase 6,Glutathione hydrolase 6 |
| Background | Antibody anti-GGT6 |
| Status | RUO |
Descripción
Gamma-glutamyltransferase 6 (GGT6) is a member of the gamma-glutamyltransferase (GGT) enzyme family involved in glutathione metabolism and cellular redox homeostasis GGT6 catalyzes the cleavage and transfer of gamma-glutamyl groups from glutathione to acceptor molecules, contributing to amino acid transport, detoxification, and antioxidant defense pathways GGT6 is primarily expressed in the kidney, liver, and reproductive tissues, where it regulates extracellular glutathione turnover and supports cellular stress responses Dysregulation of GGT6 expression has been associated with various diseases, including liver dysfunction, inflammatory disorders, and cancer, where altered glutathione metabolism promotes oxidative stress and tumor progression Studies also indicate a potential role for GGT6 in maintaining immune system function by regulating glutathione availability in immune cells While the exact physiological roles of GGT6 remain under investigation, emerging evidence suggests its importance in cellular detoxification, redox balance, and protection against oxidative damage
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