Glutamate Decarboxylase 2 (GAD2) Antibody

Description

Glutamate Decarboxylase 2 (Pancreatic Islets And Brain, 65Kda) Antibody is a Rabbit Polyclonal antibody against Glutamate Decarboxylase 2 (Pancreatic Islets And Brain, 65Kda). This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.