G-Protein Coupled Receptor 48 (GPR48) Antibody
312€ (50 µl)
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Name
G-Protein Coupled Receptor 48 (GPR48) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx147485
Tested Applications
WB
Description
GPR48 Antibody is a Rabbit Polyclonal against GPR48.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: G-Protein Coupled Receptor 48 (GPR48) Immunogen: Synthesised peptide derived from human GPR48 |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Observed MW | 104 kDa |
| Purification | Purified by affinity chromatography using epitope-specific peptide. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9BXB1 |
| Gene ID | 55366 |
| Alias | LGR4,GPR48,leucine-rich repeat-containing G protein-coupled receptor 4,leucine-rich repeat containing G protein-coupled receptor 4,DPSL,BNMD17 |
| Background | Antibody anti-LGR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
LGR4 is a member of the leucine-rich repeat-containing G protein-coupled receptor (LGR) family, which is activated by R-spondins, a group of proteins that regulate Wnt signaling. LGR4 plays a significant role in tissue development, differentiation, and homeostasis, particularly in the epithelial cells of various organs, including the gastrointestinal tract, kidney, and skin. It is involved in modulating Wnt/β-catenin signaling pathways, which are crucial for cell proliferation, stem cell maintenance, and differentiation. LGR4 is implicated in regulating processes such as embryogenesis, organogenesis, and tissue repair. Dysregulation of LGR4 signaling has been associated with conditions like cancer, particularly colorectal cancer, and disorders of tissue regeneration. LGR4 also plays a role in controlling blood pressure and fluid balance, with potential therapeutic applications in hypertension and renal diseases.
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