G-Protein Coupled Receptor 18 (GPR18) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
G-Protein Coupled Receptor 18 (GPR18) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015264
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against GPR18 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G-Protein Coupled Receptor 18 (GPR18) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14330 |
| Alias | GRP18,GPCRW,NAGly receptor,N-arachidonoyol glycine receptor,DRV2,G-Protein Coupled Receptor 18 |
| Background | Antibody anti-GPR18 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
GPR18 is an orphan G protein-coupled receptor implicated in immune regulation, lipid signaling, and cannabinoid-like responses. It is widely expressed in immune cells, the central nervous system, and peripheral tissues. GPR18 is activated by endogenous ligands, such as N-arachidonoylglycine (NAGly), and interacts with cannabinoid-like signaling pathways. GPR18 regulates immune cell migration, particularly in macrophages, microglia, and T cells, where it modulates inflammation and resolution of tissue injury. It has been linked to ocular pressure regulation in the eye, making it a potential target for treating glaucoma. In cancer, GPR18 expression promotes tumor progression, survival, and metastasis, particularly in melanoma and breast cancer, where it enhances cell migration and immune evasion. Dysregulation of GPR18 signaling has also been associated with inflammatory and neurodegenerative diseases. Its involvement in immune homeostasis and cannabinoid-like signaling makes GPR18 a promising target for therapeutic development in inflammation, cancer, and neuroimmune disorders.
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