G Protein-Coupled Receptor 1 (GPR1) Antibody (HRP)

Background

(CMKLR2), also known as GPR1, is a lesser-studied receptor within the chemerin signaling axis. CMKLR2 binds chemerin-derived peptides, though its affinity and downstream signaling pathways differ slightly from CMKLR1. CMKLR2 is expressed in neuronal tissues, endothelial cells, and adipocytes, suggesting diverse roles in metabolism and immune regulation. While its function remains under investigation, CMKLR2 is believed to modulate neuroinflammation and glucose homeostasis. In metabolic tissues, CMKLR2 influences insulin signaling and adipocyte differentiation, contributing to energy storage and utilization. In the central nervous system, CMKLR2 is implicated in regulating neural plasticity and inflammatory responses during neurodegenerative diseases like multiple sclerosis. Recent studies also highlight its role in tumor biology, where it may support angiogenesis and tumor progression under hypoxic conditions. The overlap of CMKLR2's signaling with CMKLR1 suggests a cooperative role in immune regulation, inflammation, and metabolic disorders. Targeting CMKLR2 alongside CMKLR1 could offer a broader therapeutic strategy for obesity, autoimmune conditions, and neurological disorders.