G Protein-Coupled Receptor 1 (GPR1) Antibody (Biotin)
169€ (20 µg)
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935106861
info@markelab.com
name
G Protein-Coupled Receptor 1 (GPR1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx335849
tested applications
ELISA
Description
GPR1 Antibody (Biotin) is a Rabbit Polyclonal against GPR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | G Protein-Coupled Receptor 1 (GPR1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P46091 |
| Gene ID | 2825 |
| Alias | GPR1,G protein-coupled receptor 1,chemerin chemokine-like receptor 2,GPR1,Chemerin2 |
| Background | Antibody anti-CMKLR2 |
| Status | RUO |
Descripción
(CMKLR2), also known as GPR1, is a lesser-studied receptor within the chemerin signaling axis. CMKLR2 binds chemerin-derived peptides, though its affinity and downstream signaling pathways differ slightly from CMKLR1. CMKLR2 is expressed in neuronal tissues, endothelial cells, and adipocytes, suggesting diverse roles in metabolism and immune regulation. While its function remains under investigation, CMKLR2 is believed to modulate neuroinflammation and glucose homeostasis. In metabolic tissues, CMKLR2 influences insulin signaling and adipocyte differentiation, contributing to energy storage and utilization. In the central nervous system, CMKLR2 is implicated in regulating neural plasticity and inflammatory responses during neurodegenerative diseases like multiple sclerosis. Recent studies also highlight its role in tumor biology, where it may support angiogenesis and tumor progression under hypoxic conditions. The overlap of CMKLR2's signaling with CMKLR1 suggests a cooperative role in immune regulation, inflammation, and metabolic disorders. Targeting CMKLR2 alongside CMKLR1 could offer a broader therapeutic strategy for obesity, autoimmune conditions, and neurological disorders.
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