Fructose Bisphosphate Aldolase B (ALDOB) Antibody
52€ (10 µg)
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Name
Fructose Bisphosphate Aldolase B (ALDOB) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx014477
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against ALDOB protein. Immunogen region is Internal.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fructose Bisphosphate Aldolase B (ALDOB) Immunogen: The antiserum was produced against synthesized peptide derived from the internal region of human ALDOB. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/20000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05062 |
| Alias | ALDOB,ALDB |
| Background | Antibody anti-ALDOB |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ALDOB is a liver-specific isoform of fructose-bisphosphate aldolase that primarily participates in fructose metabolism. It catalyzes the breakdown of fructose-1,6-bisphosphate and fructose-1-phosphate into dihydroxyacetone phosphate and glyceraldehyde, which are intermediates in glycolysis and gluconeogenesis. ALDOB is highly expressed in the liver, kidney, and small intestine. Mutations in ALDOB result in hereditary fructose intolerance (HFI), an autosomal recessive disorder characterized by the toxic accumulation of fructose-1-phosphate, leading to hypoglycemia, hepatomegaly, and renal dysfunction. ALDOB’s critical role in fructose metabolism highlights its importance in dietary sugar processing and maintaining energy balance.
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