Free Fatty Acid Receptor 2 (FFAR2) Antibody (HRP)
169€ (20 µg)
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Name
Free Fatty Acid Receptor 2 (FFAR2) Antibody (HRP)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx303850
Tested Applications
ELISA
Description
FFAR2 Antibody (HRP) is a Rabbit Polyclonal against FFAR2 conjugated to HRP.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Free Fatty Acid Receptor 2 (FFAR2) Immunogen: Recombinant human Free fatty acid receptor 2 protein (277-330AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15552 |
| Gene ID | 2867 |
| OMIM | 603823 |
| Alias | FFAR2,FFA2R,GPCR3,GPR43,G protein-coupled receptor 43 |
| Background | Antibody anti-FFAR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FFAR2, also known as GPR43, is a G protein-coupled receptor that binds short-chain fatty acids (SCFAs) like acetate, propionate, and butyrate, which are produced by gut microbiota fermentation of dietary fiber. FFAR2 is expressed in immune cells, adipocytes, and the gastrointestinal tract, where it regulates energy metabolism, inflammation, and gut homeostasis. In immune cells, FFAR2 activation reduces inflammation by suppressing pro-inflammatory cytokine production and promoting anti-inflammatory responses, making it a critical modulator of immune function. In adipose tissue, FFAR2 signaling regulates lipolysis, adipogenesis, and energy expenditure, contributing to metabolic health. Dysregulation of FFAR2 has been implicated in obesity, inflammatory bowel disease (IBD), and metabolic disorders. It also plays a role in the gut-brain axis, influencing satiety and feeding behaviors. FFAR2 is a potential therapeutic target for inflammatory diseases, obesity, and metabolic dysfunction, as it links gut microbiota activity to host metabolism and immune regulation.
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