Folliculin Interacting Protein 1 (FNIP1) Antibody (Biotin)
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935106861
info@markelab.com
Precio
637€ (100 µg)
Antibody anti-FNIP1
proveedor
Abbexareference
abx447820Tested Applications
WB, IHC, IF/ICCreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
FNIP1 Antibody (Biotin) is a Rabbit Polyclonal against FNIP1.
Background
FNIP1 is a critical binding partner of folliculin (FCLN) and plays a key role in energy sensing and metabolic regulation through its interactions with AMPK and mTOR signaling pathways. FNIP1 acts as a molecular scaffold, facilitating the assembly of the FCLN-FNIP complex on lysosomal membranes, which is necessary for proper mTORC1 activation in response to nutrient and energy cues. FNIP1 also interacts with the Hsp90 chaperone system, regulating the stability and functionality of FCLN. Loss of FNIP1 impairs AMPK signaling, disrupting cellular energy homeostasis and leading to metabolic dysregulation. Studies in mouse models have shown that FNIP1 is essential for B-cell development, suggesting a broader role in lymphocyte function and immune responses. FNIP1 expression is highest in metabolically active tissues, including the heart, skeletal muscle, and kidney. Its role in coordinating FCLN function and metabolic signaling positions FNIP1 as a key regulator of cellular growth and proliferation, and its dysregulation is implicated in oncogenic and metabolic disorders.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Folliculin Interacting Protein 1 (FNIP1)
host
Rabbit
conjugation
Biotin
tested applications
WB, IHC, IF/ICC
purification
Peptide Affinity Purified
recommended dilution
WB: 1/1000, IHC: 1/50, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS, 50% glycerol, 0.09% sodium azide.
size 1
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
FNIP1
dry ice
No
availability
Shipped within 5-12 working days.
alias
IMD93,KIAA1961
uniprot id
NCBI accession
NP_001008738.2
note
Concentration: 1 mg/ml -
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