Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody
559€ (100 µl)
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Name
Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025413
Tested Applications
ELISA, WB
Description
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This antibody is supplied as crude ascites.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Immunogen: KLH-conjugated synthetic peptide between 60-88 amino acids from human FCGR3A. |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Calculated MW: 29.1 kDa |
| Purification | Unpurified crude ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08637 |
| Alias | CD16,FCG3,CD16A,FCGR3,IGFR3,IMD20,FCR-10,FCRIII,CD16-II,FCGRIII,FCRIIIA,FcGRIIIA,Low affinity immunoglobulin gamma Fc region receptor III-A,IgG Fc receptor III-A,IgG Fc receptor III-2 |
| Background | Antibody anti-FCGR3A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
FCGR3A, or Fc gamma receptor IIIa, is a membrane-bound protein that plays a crucial role in the immune system, specifically in mediating immune responses through the recognition of the Fc region of IgG antibodies. This receptor is primarily expressed on the surface of natural killer (NK) cells, macrophages, monocytes, and dendritic cells, where it facilitates antibody-dependent cellular cytotoxicity (ADCC) and other immune responses. It is part of the broader family of Fc gamma receptors (FcγRs), which are responsible for binding to the Fc region of IgG antibodies, thereby linking humoral and cellular immunity. FCGR3A has garnered considerable attention in immunology due to its role in recognizing and responding to immune complexes, infected cells, and tumor cells coated with IgG antibodies. Variations in the gene encoding FCGR3A have been implicated in differential responses to infections, autoimmune diseases, and cancer therapies
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