Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody

Este producto es parte de FCGR3A - Fc gamma receptor IIIa
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195€ (20 µl)

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935106861
info@markelab.com
name
Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001989
tested applications
ELISA, WB

Description

FCGR3A Antibody is a Rabbit Polyclonal antibody against FCGR3A. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
Fc Fragment of IgG Low Affinity IIIa Receptor (FCGR3A)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1 µg/ml, WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
20 µl
Size 2
100 µl
Size 3
2 × 100 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P08637
Gene ID
2214
NCBI Accession
NP_000560.7
Alias
CD16,FCG3,CD16A,FCGR3,IGFR3,IMD20,FCR-10,FCRIII,CD16-II,FCGRIII,FCRIIIA,FcGRIIIA,Low affinity immunoglobulin gamma Fc region receptor III-A,IgG Fc receptor III-A,IgG Fc receptor III-2
Background
Antibody anti-FCGR3A
Status
RUO
Note
Concentration: > 0.2 mg/ml -

Descripción

FCGR3A, or Fc gamma receptor IIIa, is a membrane-bound protein that plays a crucial role in the immune system, specifically in mediating immune responses through the recognition of the Fc region of IgG antibodies. This receptor is primarily expressed on the surface of natural killer (NK) cells, macrophages, monocytes, and dendritic cells, where it facilitates antibody-dependent cellular cytotoxicity (ADCC) and other immune responses. It is part of the broader family of Fc gamma receptors (FcγRs), which are responsible for binding to the Fc region of IgG antibodies, thereby linking humoral and cellular immunity. FCGR3A has garnered considerable attention in immunology due to its role in recognizing and responding to immune complexes, infected cells, and tumor cells coated with IgG antibodies. Variations in the gene encoding FCGR3A have been implicated in differential responses to infections, autoimmune diseases, and cancer therapies

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