EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Antibody (PE)
611€ (100 tests)
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935106861
info@markelab.com
name
EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Antibody (PE)
category
Primary Antibodies
provider
Abbexa
reference
abx414048
tested applications
FCM
Description
EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Antibody (PE) is a Mouse Monoclonal antibody against CD312.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 tests |
| Form | Lyophilized |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store at -20 °C or -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9UHX3 |
| Alias | ADGRE2,EMR2,EGF-like module-containing mucin-like hormone receptor-like 2,CD312 |
| Background | Antibody anti-ADGRE2 |
| Status | RUO |
Descripción
ADGRE2, or EMR2, is an adhesion GPCR expressed on myeloid cells, including monocytes, macrophages, and eosinophils, where it modulates immune responses and cellular adhesion. Its structure includes multiple extracellular EGF-like domains that enable interactions with ligands and the extracellular matrix. ADGRE2 is involved in processes such as cell migration, adhesion, and activation during inflammatory and immune responses. Mutations in ADGRE2 have been linked to vibratory urticaria, a rare inherited disorder characterized by hives triggered by mechanical vibrations, suggesting its role in mechanosensation and immune cell activation. The receptor’s involvement in eosinophil-mediated responses also points to potential roles in allergic diseases and eosinophilic inflammation.
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