EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Antibody
273€ (100 µl)
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935106861
info@markelab.com
name
EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx128952
tested applications
WB, IHC, IF/ICC
Description
EGF Like Module Containing Mucin Like Hormone Receptor 2 Antibody is a Rabbit Polyclonal against EGF Like Module Containing Mucin Like Hormone Receptor 2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | EGF Like Module Containing Mucin Like Hormone Receptor 2 (EMR2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ADGRE2,EMR2,EGF-like module-containing mucin-like hormone receptor-like 2,CD312 |
| Background | Antibody anti-ADGRE2 |
| Status | RUO |
Descripción
ADGRE2, or EMR2, is an adhesion GPCR expressed on myeloid cells, including monocytes, macrophages, and eosinophils, where it modulates immune responses and cellular adhesion. Its structure includes multiple extracellular EGF-like domains that enable interactions with ligands and the extracellular matrix. ADGRE2 is involved in processes such as cell migration, adhesion, and activation during inflammatory and immune responses. Mutations in ADGRE2 have been linked to vibratory urticaria, a rare inherited disorder characterized by hives triggered by mechanical vibrations, suggesting its role in mechanosensation and immune cell activation. The receptor’s involvement in eosinophil-mediated responses also points to potential roles in allergic diseases and eosinophilic inflammation.
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