E3 Ubiquitin-Protein Ligase UBR2 (UBR2) Antibody

Name: E3 Ubiquitin-Protein Ligase UBR2 (UBR2) Antibody
Brand: Abbexa
SKU: abx239209
Price: 364 EUR
Availability: OnlineOnly

364€ (100 µg)

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E3 Ubiquitin-Protein Ligase UBR2 (UBR2) Antibody

Description

UBR2 Antibody is a Rabbit Polyclonal against UBR2.

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Data sheet

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Product specifications

Category	Primary Antibodies
Immunogen Target	E3 Ubiquitin-Protein Ligase UBR2 (UBR2)
Host	Rabbit
Reactivity	Human, Mouse
Recommended Dilution	WB: 1/200 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Clonality	Polyclonal
Conjugation	Unconjugated
Isotype	IgG
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Size 1	100 µg
Form	Liquid
Tested Applications	ELISA, WB, IHC, IF/ICC
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-12 working days.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice	No
UniProt ID	Q8IWV8
Gene ID	23304
OMIM	609134
Background	Antibody anti-UBR2
Status	RUO
Note	Concentration: 2 mg/ml - Validity: 12 months.

Descripción

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UBR2 antibody

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.

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