E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx231318
tested applications
ELISA, WB, IHC
Description
CBLB Antibody is a Rabbit Polyclonal against CBLB.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E3 Ubiquitin-Protein Ligase CBL-B (CBLB) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13191 |
| Alias | CBL-B,CBLB,Cbl-b, RNF56, ADMIO3, Nbla00127 |
| Background | Antibody anti-CBLB |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
CBLB, another member of the CBL family, shares a similar function to CBL in ubiquitinating target proteins, but it has its unique set of substrates and regulatory roles. CBLB primarily regulates immune cell signaling, particularly in T and B cells, by modulating receptor signaling pathways involved in immune responses. It is involved in the regulation of T-cell receptor (TCR) signaling, and its activity helps in controlling the activation threshold of immune cells. Similar to CBL, CBLB can influence the stability of receptors and other signaling molecules by mediating their degradation. Altered expression or mutations in CBLB can affect immune responses, and it has been linked to autoimmune diseases and immune deficiencies.
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