E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
292.5€ (80 µl)
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935106861
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name
E3 Ubiquitin-Protein Ligase CBL-B (CBLB) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx034055
tested applications
ELISA, WB, IHC, FCM
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. It also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. It may also be involved in EGFR ubiquitination and internalization.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | E3 Ubiquitin-Protein Ligase CBL-B (CBLB) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13191 |
| Gene ID | 868 |
| OMIM | 604491 |
| Alias | CBL-B,CBLB,Cbl-b, RNF56, ADMIO3, Nbla00127 |
| Background | Antibody anti-CBLB |
| Status | RUO |
Descripción
CBLB, another member of the CBL family, shares a similar function to CBL in ubiquitinating target proteins, but it has its unique set of substrates and regulatory roles. CBLB primarily regulates immune cell signaling, particularly in T and B cells, by modulating receptor signaling pathways involved in immune responses. It is involved in the regulation of T-cell receptor (TCR) signaling, and its activity helps in controlling the activation threshold of immune cells. Similar to CBL, CBLB can influence the stability of receptors and other signaling molecules by mediating their degradation. Altered expression or mutations in CBLB can affect immune responses, and it has been linked to autoimmune diseases and immune deficiencies.
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