Transcription Factor E2F5 (E2F5) Antibody
357.5€ (100 µg)
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935106861
info@markelab.com
name
Transcription Factor E2F5 (E2F5) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx037397
tested applications
ELISA, WB
Description
Rabbit Polyclonal against the E2F5 protein.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Transcription Factor E2F5 (E2F5) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15329 |
| Gene ID | 1875 |
| NCBI Accession | NM_001083588 |
| OMIM | 600967 |
| Alias | E2F-5 |
| Background | Antibody anti-E2F5 |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
E2F5 is a transcriptional repressor that functions similarly to E2F4 in controlling cell cycle exit, quiescence, and differentiation. It forms complexes with pocket proteins such as p130 and p107 to repress proliferation-related genes, particularly during G0 and early G1 phases. E2F5 is highly expressed in non-proliferative and terminally differentiated cells, where it ensures proper tissue development and homeostasis. E2F5 plays a critical role in embryonic development, especially in the formation of the central nervous system, lungs, and cardiac tissues. Mutations in E2F5 have been linked to ciliopathies such as hydrocephalus, where impaired regulation of cilia-related genes disrupts fluid flow and tissue organization. Knockout studies reveal developmental defects, including hydrocephalus and improper cell cycle control, demonstrating E2F5’s importance in maintaining cellular quiescence, differentiation, and developmental stability.
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