E2F Transcription Factor 3 (E2F3) Antibody
195€ (20 µl)
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Name
E2F Transcription Factor 3 (E2F3) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx123826
Tested Applications
ELISA, WB
Description
E2F3 Antibody is a Rabbit Polyclonal Antibody against E2F3.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: E2F Transcription Factor 3 (E2F3) Immunogen: Synthetic peptide corresponding to E2F3. The exact sequence is proprietary. |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Assay Type | Concentration: > 0.2 mg/ml |
| Recommended Dilution | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 49 kDa Observed MW: 53 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 20 µl |
| Size 2 | 100 µl |
| Size 3 | 2 × 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00716 |
| Gene ID | 1871 |
| NCBI Accession | NP_001230005.1 |
| Alias | E2F-3,KIAA0075 |
| Background | Antibody anti-E2F3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
E2F3 is a critical transcription factor involved in cell cycle regulation, particularly during the G1-to-S phase transition. It promotes the expression of genes essential for DNA synthesis, cell proliferation, and mitotic progression, such as cyclin E and CDC6. E2F3 exists in two isoforms, E2F3a and E2F3b, which have distinct functions: E2F3a primarily drives cell proliferation, while E2F3b has roles in transcriptional repression and cellular quiescence. Dysregulation of E2F3 is associated with cancers such as bladder, lung, and prostate cancer, where its overexpression leads to uncontrolled proliferation and genomic instability. E2F3 is negatively regulated by the retinoblastoma protein (RB), and mutations in the RB pathway often result in E2F3 hyperactivity. Knockout studies demonstrate impaired cell proliferation, reduced embryonic development, and defects in organogenesis, highlighting E2F3's role in cell growth, differentiation, and tumor progression.
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