E2F Transcription Factor 1 (E2F1) Antibody

Background

E2F1 is a member of the E2F family of transcription factors, which are critical regulators of cell cycle progression, DNA replication, and apoptosis. E2F1 drives the transition from G1 to S phase by activating genes required for DNA synthesis and cell proliferation, including cyclins and replication factors. It is tightly regulated by the retinoblastoma protein (pRB), which suppresses its activity under growth-inhibitory conditions. E2F1 also induces apoptosis under cellular stress or DNA damage by activating pro-apoptotic genes such as p53 and caspases. Dysregulation of E2F1 contributes to tumorigenesis by promoting uncontrolled proliferation and resistance to cell death. In cancer, overexpression of E2F1 is often observed, correlating with poor prognosis and enhanced tumor growth. Knockout models reveal defects in cell cycle progression and reduced apoptosis, emphasizing its dual role in proliferation and programmed cell death.