Dog Orexin Receptor Type 2 (HCRTR2) ELISA Kit
715€ (96 tests)
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935106861
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name
Dog Orexin Receptor Type 2 (HCRTR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx555379
tested applications
ELISA
Description
Dog Orexin Receptor Type 2 (HCRTR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Orexin receptor type 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Orexin Receptor Type 2 (HCRTR2) |
| Reactivity | Dog |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9TUP7 |
| Alias | HCRTR2,hypocretin receptor 2,orexin receptor type 2,OX2R,OXR2,ORXR2 |
| Background | Elisa kits for HCRTR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HCRTR2 is a G protein-coupled receptor that binds both orexin-A and orexin-B, neuropeptides that regulate arousal, sleep-wake cycles, and energy balance. HCRTR2 is widely expressed in the hypothalamus, brainstem, and other CNS regions involved in sleep regulation, feeding behavior, and stress responses. HCRTR2 primarily couples to Gq proteins, activating phospholipase C (PLC), increasing intracellular calcium levels, and stimulating pathways such as MAPK and CREB. HCRTR2 plays a vital role in promoting wakefulness and preventing REM sleep, contributing to arousal stability and energy expenditure. Dysregulation of HCRTR2 is strongly linked to narcolepsy type 1, where loss of orexin-producing neurons leads to excessive sleepiness and disrupted sleep architecture. HCRTR2 agonists are being investigated as potential therapies for narcolepsy, while dual orexin receptor antagonists (targeting HCRTR1 and HCRTR2) are used to treat insomnia by promoting sleep onset and maintenance. HCRTR2’s critical role in wakefulness, stress, and metabolism highlights its therapeutic potential in sleep and neuropsychiatric disorders.
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