Dog Metalloproteinase Inhibitor 1 (TIMP1) ELISA Kit
proveedor
Abbexareference
abx150295Tested Applications
ELISAreactivity
Dogstatus
RUOclonality
Descripción
Dog Metalloproteinase Inhibitor 1 (TIMP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Dog Metalloproteinase Inhibitor 1 (TIMP1) concentrations in serum, plasma and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Tissue Inhibitors Of Metalloproteinase 1 (TIMP1)No significant cross-reactivity or interference between Tissue Inhibitors Of Metalloproteinase 1 (TIMP1) and analogues was observed.
Background
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP metallopeptidase inhibitor 1, also known as TIMP1, is expressed in various tissues of organisms. It plays a crucial role in regulating the activity of matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases (ADAMs and ADAMTSs). TIMP-1 is also involved in several other biological processes, including the regulation of growth factors, tissue remodeling, inhibition of angiogenesis (the formation of new blood vessels), influencing cell morphology (shape and structure), and stimulating gonadal steroidogenesis
Background
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. El inhibidor 1 de la metalopeptidasa IMP, también conocido como TIMP1, se expresa en varios tejidos de organismos. Desempeña un papel crucial en la regulación de la actividad de las metaloproteinasas de matriz (MMP) y las desintegrina-metaloproteinasas (ADAM y ADAMTS). TIMP-1 también participa en varios otros procesos biológicos, incluida la regulación de factores de crecimiento, la remodelación de tejidos, la inhibición de la angiogénesis (la formación de nuevos vasos sanguíneos), la influencia en la morfología celular (forma y estructura) y la estimulación de la esteroidogénesis
Características del producto
category
ELISA Kits
immunogen target
Metalloproteinase Inhibitor 1 (TIMP1)
reactivity
Dog
test range
31.2 pg/ml - 2000 pg/ml
sensitivity
< 13.2 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Serum,Plasma,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
TIMP1
dry ice
No
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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