Tissue Inhibitor of Metalloprotease 1 is a recombinant enzyme.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. TIMP metallopeptidase inhibitor 1, also known as TIMP1, is expressed in various tissues of organisms. It plays a crucial role in regulating the activity of matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases (ADAMs and ADAMTSs). TIMP-1 is also involved in several other biological processes, including the regulation of growth factors, tissue remodeling, inhibition of angiogenesis (the formation of new blood vessels), influencing cell morphology (shape and structure), and stimulating gonadal steroidogenesis
Proteins and Peptides
Human
E. coli
Metalloproteinase Inhibitor 1 (TIMP1)
E. coli
Liquid
SDS-PAGE
2 µg
10 µg
1 mg
Recombinant
> 95% (SDS-PAGE)
Store at 4 °C if the entire vial will be used within 2-4 weeks. Store at -20 °C for long term storage. Avoid repeated freeze/thaw cycles.
TIMP1
No
Shipped within 5-10 working days.
Tissue inhibitor of metalloproteinases 1,EPA,EPO,HCI,CLGI,TIMP,TIMP-1
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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