Docking Protein 8 (DOCK8) Antibody

Name: Docking Protein 8 (DOCK8) Antibody
Brand: Abbexa
SKU: abx321039
Price: 169 EUR
Availability: OnlineOnly

Este producto es parte de DOCK - Dedicator of Cytokinesis

Pida mas información

935106861

info@markelab.com

Precio

169€ (20 µl)

Antibody anti-DOCK8

proveedor

Abbexa

reference

abx321039

Tested Applications

ELISA, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

DOCK8 Antibody is a Rabbit Polyclonal against DOCK8.

Background

DOCK8 is a GEF primarily activating Rac1 and Cdc42, critical for actin cytoskeleton regulation, immune cell migration, and synapse formation. It is essential for lymphocyte survival, intercellular adhesion, and immune synapse organization. DOCK8 deficiency causes DOCK8 immunodeficiency syndrome, characterized by recurrent infections, allergies, and autoimmunity. It interacts with proteins like WASP and ELMO to promote immune cell migration and T-cell activation. DOCK8 is highly expressed in hematopoietic cells, particularly T and B cells. Dysregulation impairs lymphocyte trafficking and survival, contributing to immune dysfunction. Studies in knockout models show defects in T-cell proliferation, migration, and immune surveillance.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Docking Protein 8 (DOCK8)

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

Liquid

tested applications

ELISA, IHC, IF/ICC

purification

Antigen Affinity Chromatography.

recommended dilution

IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

buffer

PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.

size 1

20 µl

size 2

50 µl

size 3

100 µl

size 4

200 µl

size 5

1 ml

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

DOCK8

dry ice

availability

Shipped within 5-10 working days.

alias

HEL-205,HIES2,MRD2,ZIR8

uniprot id

https://www.uniprot.org/uniprotkb/Q8NF50

gene id

https://www.ncbi.nlm.nih.gov/gene/81704

NCBI accession

NP_001177387.1, NM_001190458.1, NP_001180465.1, NM_001193536.1, NP_982272.2, NM_203447.3

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anti- DOCK8 antibody

proveedor

FineTest

reference

FNab02498

Tested Applications

ELISA, WB, IHC

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

Potential guanine nucleotide exchange factor(GEF). GEF proteins activate some small GTPases by exchanging bound GDP for ...

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