Docking Protein 8 (DOCK8) Antibody

Background

DOCK8 is a GEF primarily activating Rac1 and Cdc42, critical for actin cytoskeleton regulation, immune cell migration, and synapse formation. It is essential for lymphocyte survival, intercellular adhesion, and immune synapse organization. DOCK8 deficiency causes DOCK8 immunodeficiency syndrome, characterized by recurrent infections, allergies, and autoimmunity. It interacts with proteins like WASP and ELMO to promote immune cell migration and T-cell activation. DOCK8 is highly expressed in hematopoietic cells, particularly T and B cells. Dysregulation impairs lymphocyte trafficking and survival, contributing to immune dysfunction. Studies in knockout models show defects in T-cell proliferation, migration, and immune surveillance.