Docking Protein 8 (DOCK8) Antibody
364€ (100 µg)
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935106861
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name
Docking Protein 8 (DOCK8) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx232498
tested applications
ELISA, WB, IHC
Description
DOCK8 Antibody is a Rabbit Polyclonal against DOCK8.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 8 (DOCK8) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8NF50 |
| Gene ID | 81704 |
| OMIM | 243700 |
| Alias | HEL-205,HIES2,MRD2,ZIR8 |
| Background | Antibody anti-DOCK8 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
DOCK8 is a GEF primarily activating Rac1 and Cdc42, critical for actin cytoskeleton regulation, immune cell migration, and synapse formation. It is essential for lymphocyte survival, intercellular adhesion, and immune synapse organization. DOCK8 deficiency causes DOCK8 immunodeficiency syndrome, characterized by recurrent infections, allergies, and autoimmunity. It interacts with proteins like WASP and ELMO to promote immune cell migration and T-cell activation. DOCK8 is highly expressed in hematopoietic cells, particularly T and B cells. Dysregulation impairs lymphocyte trafficking and survival, contributing to immune dysfunction. Studies in knockout models show defects in T-cell proliferation, migration, and immune surveillance.
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