Docking Protein 6 (DOK6) Antibody (HRP)
169€ (20 µg)
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935106861
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name
Docking Protein 6 (DOK6) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx303659
tested applications
ELISA
Description
DOK6 Antibody (HRP) is a Rabbit Polyclonal against DOK6 conjugated to HRP.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 6 (DOK6) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6PKX4 |
| Gene ID | 220164 |
| OMIM | 611402 |
| Alias | Downstream of tyrosine kinase 6,DOK5L |
| Background | Antibody anti-DOK6 |
| Status | RUO |
Descripción
DOK6 is an adaptor protein in the DOK family that interacts with RET and other receptor tyrosine kinases, promoting neuronal development and survival. It is highly expressed in the nervous system, particularly in sensory and motor neurons, where it regulates neurite outgrowth and axonal guidance through the activation of MAPK/ERK pathways. DOK6 interacts with signaling proteins via its PTB and PH domains to mediate downstream effects. It plays a role in neurotrophic signaling, and its dysregulation is linked to impaired neural differentiation and neurodevelopmental disorders. Studies highlight its importance in promoting axonal elongation and neuronal connectivity.
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