Docking Protein 6 (DOK6) Antibody
52€ (10 µg)
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935106861
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name
Docking Protein 6 (DOK6) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx013664
tested applications
ELISA, WB, IF/ICC
Description
Rabbit polyclonal antibody against DOK6 protein. Immunogen region is Internal.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Docking Protein 6 (DOK6) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/500 - 1/3000, IF/ICC: 1/100 - 1/500, ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6PKX4 |
| Alias | Downstream of tyrosine kinase 6,DOK5L |
| Background | Antibody anti-DOK6 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
DOK6 is an adaptor protein in the DOK family that interacts with RET and other receptor tyrosine kinases, promoting neuronal development and survival. It is highly expressed in the nervous system, particularly in sensory and motor neurons, where it regulates neurite outgrowth and axonal guidance through the activation of MAPK/ERK pathways. DOK6 interacts with signaling proteins via its PTB and PH domains to mediate downstream effects. It plays a role in neurotrophic signaling, and its dysregulation is linked to impaired neural differentiation and neurodevelopmental disorders. Studies highlight its importance in promoting axonal elongation and neuronal connectivity.
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